HRID403864

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85588

2-Fluorophenyl isocyanate

C7H4FNO

结构：COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)ccc2C1=O

HCID123620640

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(N)cc3)ccc2C1=O

HCID131731499

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)ccc2C1=O

HCID131731501

未命名化合物

PROCEDURE

实验过程

The compound of example 226 was prepared analogous to compound of example 224 by reaction of compound of example 223 with 2-fluoro phenyl isocyanate. The compound of example 226 was used directly without isolation for the preparation of compound of example 227.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4638d706dad41f18db85703a101cd93
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

FC1C=CC([NH:8][C:9](=[O:35])[NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[C:22](=[O:26])[N:21]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[CH2:20]4)=[CH:13][CH:12]=2)=CC=1.NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(OC)=O)C3)=CC=1.[F:61][C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][C:63]=1N=C=O>>[F:61][C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][C:63]=1[NH:8][C:9](=[O:35])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[C:22](=[O:26])[N:21]([C@@H:27]([CH:32]([CH3:33])[CH3:34])[C:28]([O:30][CH3:31])=[O:29])[CH2:20]3)=[CH:13][CH:12]=1