HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluorophenyl isocyanate → (S)-Methyl 2-(5-(4-(3-(2,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluorophenyl isocyanate | HCID 593258 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(4-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123620640 | — |
| Reactant | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Product | (S)-Methyl 2-(5-(4-(3-(2,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731503 | — |
Reaction Steps
The compound of example 236 was prepared analogous to compound of example 224 by reaction of compound of example 223 with 2,4-difluorophenyl isocyanate. The compound of example 236 was used directly without isolation for the preparation of compound of example 237.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-d9d3e7bca2f6455d8380d2f8bae73ef5 |
| Source note | uspto-grants-2014_06 |