HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(5-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(5-(4-(3-(2,4-Difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(5-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 67306564 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(2,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731503 | — |
| Product | (S)-2-(5-(4-(3-(2,4-Difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 67306599 | 89% |
Reaction Steps
The compound of example 237 was prepared analogous to compound of example 225 by hydrolysis of compound of example 236.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-968b52bcc68043b5a6bb29e1a871b120 |
| Source note | uspto-grants-2014_06 |