HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenyl isocyanate → (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenyl isocyanate | HCID 73768 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(4-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123620640 | — |
| Reactant | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Product | (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoate | HCID 131731504 | — |
Reaction Steps
The compound of example 244 was prepared analogous to compound of example 224 by reaction of compound of example 223 with 4-trifluoromethyl phenyl isocyanate. The compound of example 244 was used directly without isolation for the preparation of compound of example 245.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-476226d98aa4407397f1f7ad5299d9d3 |
| Source note | uspto-grants-2014_06 |