HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenyl isothiocyanate → (S)-Methyl 2-(5-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenyl isothiocyanate | HCID 16480 | — |
| Reactant | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731509 | — |
| Product | (S)-Methyl 2-(5-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731512 | — |
Reaction Steps
The compound of example 264 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 4-chlorophenyl isothiocyanate. The compound of example 264 was used directly without isolation for the preparation of compound of example 265.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-6cecb117725740f9b412e3f5c7315e02 |
| Source note | uspto-grants-2014_06 |