HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(5-(4-(3-(3-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 87349473 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(3-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731513 | — |
| Product | (S)-2-(5-(4-(3-(3-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 87349424 | 92% |
Reaction Steps
The compound of example 267 was prepared analogous to compound of example 257 by hydrolysis of compound of example 266.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-e5513a2b7d274a15b23ff3a821711ca5 |
| Source note | uspto-grants-2014_06 |