HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 4-isothiocyanato- → (S)-Methyl 2-(5-(4-(3-(4-cyanophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 4-isothiocyanato- | HCID 17626 | — |
| Reactant | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731509 | — |
| Product | (S)-Methyl 2-(5-(4-(3-(4-cyanophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731514 | — |
Reaction Steps
The compound of example 268 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 4-cyanophenyl isothiocyanate. The compound of example 268 was used directly without isolation for the preparation of compound of example 269.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b08748932f694bfaa00819f3c53e2fa3 |
| Source note | uspto-grants-2014_06 |