HRID403898

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@@H](C(=O)O)N1Cc2cc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)ccc2C1=O

HCID87349473

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2cc(-c3ccc(NC(=S)Nc4ccccc4C)cc3)ccc2C1=O

HCID131731516

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1NC(=S)Nc1ccc(-c2ccc3c(c2)CN([C@H](C(=O)O)C(C)C)C3=O)cc1

HCID53304155

未命名化合物

收率 88%

PROCEDURE

实验过程

The compound of example 273 was prepared analogous to compound of example 257 by hydrolysis of compound of example 272.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-948cd45fc2a740d7ba7abbaa8e808f0a
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

FC1C=CC=CC=1NC(=S)NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(O)=O)C3)=CC=1.[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][CH:46]=[C:47]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=4[CH3:67])=[S:59])=[CH:53][CH:52]=3)[CH:48]=2)[C:43]1=[O:68])[C:38]([O:40]C)=[O:39]>>[CH3:35][CH:36]([CH3:69])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][CH:46]=[C:47]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:66]=[CH:65][CH:64]=[CH:63][C:62]=4[CH3:67])=[S:59])=[CH:53][CH:52]=3)[CH:48]=2)[C:43]1=[O:68])[C:38]([OH:40])=[O:39]