(S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-3-Methyl-2-(1-oxo-5-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 87349473	—
Reactant	(S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoate	HCID 131731517	—
Product	(S)-3-Methyl-2-(1-oxo-5-(4-(3-p-tolylthioureido)phenyl)isoindolin-2-yl)butanoic acid	HCID 87349377	75%

The compound of example 275 was prepared analogous to compound of example 257 by hydrolysis of compound of example 274.