HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isothiocyanato-3-(trifluoromethyl)benzene → (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isothiocyanato-3-(trifluoromethyl)benzene | HCID 137232 | — |
| Reactant | (S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731499 | — |
| Reactant | (S)-Methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731509 | — |
| Product | (S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate | HCID 131731519 | — |
Reaction Steps
The compound of example 282 was prepared analogous to compound of example 256 by reaction of compound of example 223 with 3-trifluoromethyl phenyl isothiocyanate. The compound of example 282 was used directly without isolation, for the preparation of compound of example 283.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-13098a6ac51748879d41339d34e3d28f |
| Source note | uspto-grants-2014_06 |