(S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(5-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 87349473	—
Reactant	(S)-Methyl 3-methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoate	HCID 131731519	—
Product	(S)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)thioureido)phenyl)isoindolin-2-yl)butanoic acid	HCID 87350055	77%

The compound of example 283 was prepared analogous to compound of example 257 by hydrolysis of compound of example 282.