4-Cyanobenzenesulfonyl chloride → HCID 131731520, compound

HRID 403910Notes

Reaction equation

HRID 403910 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[C:26]([C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1)#[N:27]>>[C:26]([C:28]1[CH:29]=[CH:30][C:31]([S:34]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:9]=[C:10]4[C:14](=[CH:15][CH:16]=3)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]4)=[CH:4][CH:3]=2)(=[O:36])=[O:35])=[CH:32][CH:33]=1)#[N:27]

Participants

3

Reactant 2

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731520HCID 131731520, compound

Procedure

The compound of example 286 was prepared analogous to compound of example 284 by reaction of compound of example 223 with 4-cyanobenzene sulfonyl chloride. The compound of example 286 was used directly without isolation, for the preparation of compound of example 287.

Sources & evidence

ORD record
ord-ad4cd4d4b67842609e64f14f4fba5eaa
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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