2,4-Difluorobenzenesulfonyl Chloride → HCID 131731521, compound

HRID 403911Notes

Reaction equation

HRID 403911 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[S:34](Cl)(=[O:36])=[O:35]>>[F:26][C:27]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=1[S:34]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1)(=[O:36])=[O:35]

Participants

3

Reactant 2

HCID 27342732,4-Difluorobenzenesulfonyl ChlorideHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731521HCID 131731521, compound

Procedure

The compound of example 290 was prepared analogous to compound of example 284 by reaction of compound of example 223 with 2,4-difluoro benzene sulfonyl chloride. The compound of example 290 was used directly without isolation, for the preparation of compound of example 291.

Sources & evidence

ORD record
ord-2b3b108939ff46ec955ba3475b8965c8
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…