4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 131731522, compound

HRID 403914Notes

Reaction equation

HRID 403914 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[F:26][C:27]([F:39])([F:38])[C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([NH:1][S:34]([C:31]4[CH:30]=[CH:29][C:28]([C:27]([F:26])([F:38])[F:39])=[CH:33][CH:32]=4)(=[O:36])=[O:35])=[CH:3][CH:4]=3)[CH:9]=2)[C:13]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731522HCID 131731522, compound

Procedure

The compound of example 298 was prepared analogous to compound of example 284 by reaction of compound of example 223 with 4-trifluoromethyl benzene sulfonyl chloride. The compound of example 298 was used directly without isolation, for the preparation of compound of example 299.

Sources & evidence

ORD record
ord-4a4a6ae3c9c24a5587e61cbcbce678b1
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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