Cyclohexanesulfonyl chloride → HCID 131731523, compound

HRID 403916Notes

Reaction equation

HRID 403916 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[CH:26]1([S:32](Cl)(=[O:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:26]1([S:32]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:9]=[C:10]4[C:14](=[CH:15][CH:16]=3)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]4)=[CH:4][CH:3]=2)(=[O:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 237554Cyclohexanesulfonyl chlorideHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731523HCID 131731523, compound

Procedure

The compound of example 302 was prepared analogous to compound of example 284 by reaction of compound of example 223 with cyclohexyl sulfonyl chloride. The compound of example 302 was used directly without isolation, for the preparation of compound of example 303.

Sources & evidence

ORD record
ord-0aca6f6e021b4acdaee0f7ec00e305b8
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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