HCID 67307075, compound → HCID 70975429, compound

HRID 403919Notes

Reaction equation

HRID 403919 reaction equation
C(NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(O)=O)C3)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:69])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][CH:44]=[C:45]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:67])[C:57]4[CH:62]=[CH:61][C:60]([C:63]([F:66])([F:65])[F:64])=[CH:59][CH:58]=4)=[CH:51][CH:50]=3)[CH:46]=2)[C:41]1=[O:68])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:69])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][CH:44]=[C:45]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56](=[O:67])[C:57]4[CH:62]=[CH:61][C:60]([C:63]([F:66])([F:64])[F:65])=[CH:59][CH:58]=4)=[CH:53][CH:54]=3)[CH:46]=2)[C:41]1=[O:68])[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 67307075HCID 67307075, compoundHCID 131731525HCID 131731525, compound

Product 1

HCID 70975429HCID 70975429, compoundYield 95%

Procedure

The compound of example 309 was prepared analogous to compound of example 305 by hydrolysis of compound of example 308.

Sources & evidence

ORD record
ord-52e8ce7d2d0a4d1da17c1786ca2932e9
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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