HCID 87349807, compound → HCID 131731527, compound

HRID 403922Notes

Reaction equation

HRID 403922 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[F:26][C:27]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:28]=1[C:29](Br)=[O:30]>>[F:26][C:27]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:28]=1[C:29]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1)=[O:30]

Participants

3

Reactant 2

HCID 87349807HCID 87349807, compoundHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731527HCID 131731527, compound

Procedure

The compound of example 316 was prepared analogous to compound of example 304 by reaction of compound of example 223 with 2,4-difluoro benzoyl bromide. The compound of example 316 was used directly without isolation, for the preparation of compound of example 317.

Sources & evidence

ORD record
ord-10a85556b98841408d52f37ac7b573d6
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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