HCID 67307075, compound → HCID 67306743, compound

HRID 403923Notes

Reaction equation

HRID 403923 reaction equation
C(NC1C=CC(C2C=C3C(=CC=2)C(=O)N([C@@H](C(C)C)C(O)=O)C3)=CC=1)(=O)C1C=CC=CC=1.[F:33][C:34]1[CH:66]=[C:65]([F:67])[CH:64]=[CH:63][C:35]=1[C:36]([NH:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]2[CH:46]=[C:47]3[C:51](=[CH:52][CH:53]=2)[C:50](=[O:54])[N:49]([C@@H:55]([CH:60]([CH3:62])[CH3:61])[C:56]([O:58]C)=[O:57])[CH2:48]3)=[CH:41][CH:40]=1)=[O:37]>>[F:33][C:34]1[CH:66]=[C:65]([F:67])[CH:64]=[CH:63][C:35]=1[C:36]([NH:38][C:39]1[CH:40]=[CH:41][C:42]([C:45]2[CH:46]=[C:47]3[C:51](=[CH:52][CH:53]=2)[C:50](=[O:54])[N:49]([C@@H:55]([CH:60]([CH3:62])[CH3:61])[C:56]([OH:58])=[O:57])[CH2:48]3)=[CH:43][CH:44]=1)=[O:37]

Participants

3

Reactant 2

HCID 67307075HCID 67307075, compoundHCID 131731527HCID 131731527, compound

Product 1

HCID 67306743HCID 67306743, compoundYield 87%

Procedure

The compound of example 317 was prepared analogous to compound of example 305 by hydrolysis of compound of example 316.

Sources & evidence

ORD record
ord-ade547a3962641909f4804f787b1dc7b
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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