HCID 11063418, compound → HCID 131731528, compound

HRID 403924Notes

Reaction equation

HRID 403924 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[CH3:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Br)=[O:32])=[CH:29][CH:28]=1>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([NH:1][C:31](=[O:32])[C:30]4[CH:34]=[CH:35][C:27]([CH3:26])=[CH:28][CH:29]=4)=[CH:3][CH:4]=3)[CH:9]=2)[C:13]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 11063418HCID 11063418, compoundHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731528HCID 131731528, compound

Procedure

The compound of example 318 was prepared analogous to compound of example 304 by reaction of compound of example 223 with 4-methyl benzoyl bromide. The compound of example 318 was used directly without isolation, for the preparation of compound of example 319.

Sources & evidence

ORD record
ord-730869e03e304c148f191bb703ad7fa1
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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