HCID 20559000, compound → HCID 131731529, compound

HRID 403926Notes

Reaction equation

HRID 403926 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]3)=[CH:4][CH:3]=1.[C:26]([C:30]1[CH:38]=[CH:37][C:33]([C:34](Br)=[O:35])=[CH:32][CH:31]=1)([CH3:29])([CH3:28])[CH3:27]>>[C:26]([C:30]1[CH:31]=[CH:32][C:33]([C:34]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:9]=[C:10]4[C:14](=[CH:15][CH:16]=3)[C:13](=[O:17])[N:12]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[CH2:11]4)=[CH:4][CH:3]=2)=[O:35])=[CH:37][CH:38]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 20559000HCID 20559000, compoundHCID 131731499(S)-Methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731529HCID 131731529, compound

Procedure

The compound of example 322 was prepared analogous to compound of example 304 by reaction of compound of example 223 with 4-(t-butyl)benzoyl bromide. The compound of example 322 was used directly without isolation, for the preparation of compound of example 323.

Sources & evidence

ORD record
ord-4fadf8f1b58c4cd7b51586a662a73a28
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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