HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea → Methyl 2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | HCID 16125103 | — |
| Reactant | (R)-Methyl-3-methyl-2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoate | HCID 67306227 | — |
| Reactant | Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)acetate | HCID 67307273 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-(1-oxo-6-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)acetate | HCID 67307468 | — |
Reaction Steps
The compound of example 333 was prepared analogous to compound of example 330 by reaction of the compound of example 332, compound of example 327 and Pd(dppf)Cl2: CH2Cl2. The compound of example 333 was used directly without isolation for the preparation of compound of example 334.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-f20b0f6b505a4eebae8dd7eef50efbd1 |
| Source note | uspto-grants-2014_06 |