HRID403938

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID67306771

未命名化合物

结构：COC(=O)[C@H](C)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID131731531

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID67307601

未命名化合物

收率 82%

PROCEDURE

实验过程

The compound of example 337 was prepared analogous to compound of example 331 by hydrolysis of the compound of example 336.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ce108e34c0543d28643071f2059d5f2
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C[CH:2](C)[C@@H:3]([N:7]1[CH2:15][C:14]2[C:9](=[CH:10][C:11]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=4)=[O:24])=[CH:18][CH:17]=3)=[CH:12][CH:13]=2)[C:8]1=[O:36])[C:4]([OH:6])=[O:5].O=C1C2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)CN1[C@@H](C)C(OC)=O>>[O:36]=[C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:34])([F:33])[F:35])[CH:27]=4)=[O:24])=[CH:18][CH:17]=3)[CH:10]=2)[CH2:15][N:7]1[C@@H:3]([CH3:2])[C:4]([OH:6])=[O:5]