Methyl 2-aminoisobutyrate hydrochloride → Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-2-methylpropanoate

HRID 403939Notes

Reaction equation

HRID 403939 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.[CH3:21]OC(=O)C(C)(C)N>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C:12]([CH3:17])([CH3:21])[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13258034Methyl 2-aminoisobutyrate hydrochlorideHCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67306213Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-2-methylpropanoate

Procedure

The compound of example 338 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and 2,2-dimethyl glycine methyl ester hydrochloride.

Sources & evidence

ORD record
ord-053b43a1fb324ab9b547b847124829c0
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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