HRID403941

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID67306771

未命名化合物

结构：COC(=O)C(C)(C)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID67307788

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID67306198

未命名化合物

收率 87%

PROCEDURE

实验过程

The compound of example 340 was prepared analogous to compound of example 331 by hydrolysis of the compound of example 339.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c10a176df9384fb8ae6c2627a848680d
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

CC(C)[C@@H](N1CC2C(=CC(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)=CC=2)C1=O)C(O)=O.[CH3:38][C:39]([N:45]1[CH2:53][C:52]2[C:47](=[CH:48][C:49]([C:54]3[CH:59]=[CH:58][C:57]([NH:60][C:61]([NH:63][C:64]4[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:73])([F:72])[F:71])[CH:65]=4)=[O:62])=[CH:56][CH:55]=3)=[CH:50][CH:51]=2)[C:46]1=[O:74])([CH3:44])[C:40]([O:42]C)=[O:41]>>[CH3:44][C:39]([N:45]1[CH2:53][C:52]2[C:47](=[CH:48][C:49]([C:54]3[CH:59]=[CH:58][C:57]([NH:60][C:61]([NH:63][C:64]4[CH:69]=[CH:68][CH:67]=[C:66]([C:70]([F:72])([F:73])[F:71])[CH:65]=4)=[O:62])=[CH:56][CH:55]=3)=[CH:50][CH:51]=2)[C:46]1=[O:74])([CH3:38])[C:40]([OH:42])=[O:41]