Methyl 1-amino-1-cyclopentanecarboxylate, HCl → Methyl 1-(6-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

HRID 403942Notes

Reaction equation

HRID 403942 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C@H:12]([CH:17]([CH3:19])C)[C:13]([O:15][CH3:16])=[O:14])[C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.N[C:22]1(C(OC)=O)CCC[CH2:23]1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][N:7]([C:12]3([C:13]([O:15][CH3:16])=[O:14])[CH2:17][CH2:19][CH2:23][CH2:22]3)[C:8]2=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11513856Methyl 1-amino-1-cyclopentanecarboxylate, HClHCID 131731530(R)-Methyl 2-(6-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67313241Methyl 1-(6-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

Procedure

The compound of example 341 was prepared analogous to compound of example 329 by reaction of the compound of example 328 and methyl 1-aminocyclopentanecarboxylate hydrochloride.

Sources & evidence

ORD record
ord-e73e97fb77a74ec8a99715e0818ece2b
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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