Benzoyl Peroxide → Methyl 4-bromo-2-(bromomethyl)benzoate

Participants

Reaction Conditions

Reaction Steps

Methyl 4-bromo-2-methylbenzoate (9.6 g, 0.42 mol) was dissolved in carbon tetrachloride (150 mL). Benzoyl peroxide (250 mg) and NBS (7.6 g, 0.42 mol) were added and the reaction mixture was refluxed at 80° C. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered through celite. The filtrate was concentrated to obtain a crude material containing 85% mono bromo and 10% dibromo product. The crude product obtained was used directly, without purification for preparation of compound of example 359.

Provenance & Evidence