Methyl 4-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoate → 4-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403971Notes

Reaction equation

HRID 403971 reaction equation
CC(C)[C@@H](N1CC2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)C1=O)C(O)=O.[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:67])([F:66])[F:65])[CH:59]=4)=[O:56])=[CH:50][CH:49]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[CH2:68][CH2:69][CH2:70][C:71]([O:73]C)=[O:72]>>[O:38]=[C:39]1[C:47]2[C:42](=[CH:43][C:44]([C:48]3[CH:49]=[CH:50][C:51]([NH:54][C:55]([NH:57][C:58]4[CH:63]=[CH:62][CH:61]=[C:60]([C:64]([F:66])([F:65])[F:67])[CH:59]=4)=[O:56])=[CH:52][CH:53]=3)=[CH:45][CH:46]=2)[CH2:41][N:40]1[CH2:68][CH2:69][CH2:70][C:71]([OH:73])=[O:72]

Participants

3

Reactant 2

HCID 67307663Methyl 4-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoateHCID 67308300(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acid

Product 1

HCID 673062464-(1-Oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acidYield 89%

Procedure

The compound of example 376 was prepared analogous to the compound of example 361 by hydrolysis of the compound of example 375.

Sources & evidence

ORD record
ord-ebb4631f0b3b425896c46f174d3ed810
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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