Methyl 4-bromo-2-(bromomethyl)benzoate → HCID 131731542, compound

HRID 403977Notes

Reaction equation

HRID 403977 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@H:12]([CH:17](C)C)[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2.BrC1C=CC([C:25](OC)=[O:26])=C(CBr)C=1.Cl.NC(COC)C(OC)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C@@H:12]([CH2:17][O:26][CH3:25])[C:13]([O:15][CH3:16])=[O:14])[CH2:5]2

Participants

4

Reactant 3

HCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 22492067HCID 22492067, compoundHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731542HCID 131731542, compound

Procedure

The compound of example 383 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and methyl 2-amino-3-methoxypropanoate hydrochloride.

Sources & evidence

ORD record
ord-17ca72bae8ad4fc8bc4348e848bdc5fe
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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