HRID403978

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16125103

未命名化合物

HCID131731536

未命名化合物

HCID131731542

未命名化合物

PRODUCTS

产物

HCID131731543

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418228

Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)

C34H28Cl2FeP2Pd

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The compound of example 384 was prepared analogous to compound of example 360 by reaction of the compound of example 383, compound of example 357 and Pd(dppf)Cl2: CH2Cl2. The compound of example 384 was directly used for the preparation of compound of example 385 without purification.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-cd69bea03dde4a009b5e7e4ebfd049c9
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08748426B2
来源说明: uspto-grants-2014_06

反应SMILES

C[CH:2](C)[C@@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)=[O:25])=[CH:19][CH:18]=3)[CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].BrC1C=C2C(=CC=1)[C:45](=[O:49])N([C@@H](COC)C(OC)=O)C2.CC1(C)C(C)(C)OB(C2C=CC(NC(NC3C=CC=C(C(F)(F)F)C=3)=O)=CC=2)O1>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[CH3:45][O:49][CH2:2][C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:34])([F:36])[F:35])[CH:28]=4)=[O:25])=[CH:19][CH:18]=3)[CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5]