Methyl leucinate hydrochloride (1:1) → HCID 131731544, compound

HRID 403980Notes

Reaction equation

HRID 403980 reaction equation
BrC1C=C2C(=CC=1)C(=O)N([C@H](C(C)C)C(OC)=O)C2.[Br:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27]C)=O)=[C:23]([CH2:31]Br)[CH:22]=1.Cl.[NH2:34][CH:35]([CH2:40][CH:41]([CH3:43])[CH3:42])[C:36]([O:38][CH3:39])=[O:37]>>[Br:20][C:21]1[CH:22]=[C:23]2[C:24](=[CH:29][CH:30]=1)[C:25](=[O:27])[N:34]([C@@H:35]([CH2:40][CH:41]([CH3:43])[CH3:42])[C:36]([O:38][CH3:39])=[O:37])[CH2:31]2

Participants

4

Reactant 3

HCID 3084016Methyl leucinate hydrochloride (1:1)HCID 22031079Methyl 4-bromo-2-(bromomethyl)benzoateHCID 86673568(R)-Methyl 2-(5-bromo-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731544HCID 131731544, compound

Procedure

The compound of example 386 was prepared analogous to compound of example 359 by reaction of the compound of example 358 and methyl 2-amino-4-methylpentanoate hydrochloride.

Sources & evidence

ORD record
ord-3eba378e962949ffa797778bdd0b5678
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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