(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acid → HCID 53302547, compound

HRID 403982Notes

Reaction equation

HRID 403982 reaction equation
CC(C)[C@@H](N1CC2C(=CC=C(C3C=CC(NC(NC4C=CC=C(C(F)(F)F)C=4)=O)=CC=3)C=2)C1=O)C(O)=O.[CH3:38][CH:39]([CH3:76])[CH2:40][C@H:41]([N:46]1[CH2:54][C:53]2[C:48](=[CH:49][CH:50]=[C:51]([C:55]3[CH:60]=[CH:59][C:58]([NH:61][C:62]([NH:64][C:65]4[CH:70]=[CH:69][CH:68]=[C:67]([C:71]([F:74])([F:73])[F:72])[CH:66]=4)=[O:63])=[CH:57][CH:56]=3)[CH:52]=2)[C:47]1=[O:75])[C:42]([O:44]C)=[O:43]>>[CH3:38][CH:39]([CH3:76])[CH2:40][C@H:41]([N:46]1[CH2:54][C:53]2[C:48](=[CH:49][CH:50]=[C:51]([C:55]3[CH:56]=[CH:57][C:58]([NH:61][C:62]([NH:64][C:65]4[CH:70]=[CH:69][CH:68]=[C:67]([C:71]([F:74])([F:72])[F:73])[CH:66]=4)=[O:63])=[CH:59][CH:60]=3)[CH:52]=2)[C:47]1=[O:75])[C:42]([OH:44])=[O:43]

Participants

3

Reactant 2

HCID 67308300(R)-3-Methyl-2-(1-oxo-5-(4-(3-(3-(trifluoromethyl)phenyl)ureido)phenyl)isoindolin-2-yl)butanoic acidHCID 131731545HCID 131731545, compound

Product 1

HCID 53302547HCID 53302547, compoundYield 88%

Procedure

The compound of example 388 was prepared analogous to the compound of example 361 by hydrolysis of the compound of example 387.

Sources & evidence

ORD record
ord-2607f8ba56c341eebd7140853562bc57
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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