HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluorophenyl isocyanate → (S)-Methyl 2-(6-(5-(3-(3,4-difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluorophenyl isocyanate | HCID 2734708 | — |
| Reactant | (S)-Methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731548 | — |
| Reactant | (S)-Methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731549 | — |
| Product | (S)-Methyl 2-(6-(5-(3-(3,4-difluorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 67323403 | 89% |
Reaction Steps
The compound of example 399 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 3,4-difluoro phenyl isocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-08db04e440144962bbd0bd3e47b5bf16 |
| Source note | uspto-grants-2014_06 |