HRID403993

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cn3)cc2C1=O

HCID131731548

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)Nc4ccccc4Cl)cn3)cc2C1=O

HCID131731549

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)Nc4ccc5c(c4)CCC5)cn3)cc2C1=O

HCID131731551

未命名化合物

PROCEDURE

实验过程

The compound of example 401 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 2,3-dihydro-1H-indene-5-isocyanate. The compound of example 401 was used directly for the preparation of compound 402 without purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-99ecd00a47cc4909968b0e6691829cdc
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:35])[NH:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[N:15][CH:16]=1.N[C:37]1[CH:38]=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=N[CH:42]=1>>[CH2:42]1[C:6]2[C:5](=[CH:4][C:3]([NH:8][C:9](=[O:35])[NH:10][C:11]3[CH:12]=[CH:13][C:14]([C:17]4[CH:25]=[C:24]5[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:33])[CH3:34])[C:28]([O:30][CH3:31])=[O:29])[C:23]5=[O:26])=[CH:19][CH:18]=4)=[N:15][CH:16]=3)=[CH:2][CH:7]=2)[CH2:38][CH2:37]1