HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(6-(5-(3-(2-Chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(3-(2-Chlorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(6-(5-(3-(2-Chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 70975553 | — |
| Reactant | (S)-Methyl 2-(6-(4-(3-(2-chlorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731556 | — |
| Product | (S)-2-(6-(4-(3-(2-Chlorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 70975411 | 97% |
Reaction Steps
The compound of example 416 was prepared analogous to the compound of example 394 by hydrolysis of the compound of example 415.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-583755a06cf543289754e6372123b3c5 |
| Source note | uspto-grants-2014_06 |