(S)-2-(6-(5-(3-(2-Chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(3-(3,4-Difluorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(5-(3-(2-Chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 70975553	—
Reactant	(S)-Methyl 2-(6-(4-(3-(3,4-difluorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731557	—
Product	(S)-2-(6-(4-(3-(3,4-Difluorophenyl)ureido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 53302550	87%

The compound of example 418 was prepared analogous to the compound of example 394 by hydrolysis of the compound of example 417.