(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → (S)-2-(6-(4-(2-Naphthamido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid	HCID 67306402	—
Reactant	(S)-Methyl 2-(6-(4-(2-naphthamido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731561	—
Product	(S)-2-(6-(4-(2-Naphthamido)-2-(trifluoromethyl)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 70975556	85%

The compound of example 428 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 427.