HRID404008

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(C)(C)C)cc4)cn3)cc2C1=O

HCID67306402

未命名化合物

结构：CCCCOc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)C(=O)N([C@H](C(=O)OC)C(C)C)C4)c(C(F)(F)F)c2)cc1

HCID131731562

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1ccc(C(=O)Nc2ccc(-c3ccc4c(c3)C(=O)N([C@H](C(=O)O)C(C)C)C4)c(C(F)(F)F)c2)cc1

HCID70975166

未命名化合物

收率 82%

PROCEDURE

实验过程

The compound of example 432 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 431.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-619d07f5c37547a0a83726dc57a118f3
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[CH2:37]([O:41][C:42]1[CH:78]=[CH:77][C:45]([C:46]([NH:48][C:49]2[CH:54]=[CH:53][C:52]([C:55]3[CH:63]=[C:62]4[C:58]([CH2:59][N:60]([C@@H:65]([CH:70]([CH3:72])[CH3:71])[C:66]([O:68]C)=[O:67])[C:61]4=[O:64])=[CH:57][CH:56]=3)=[C:51]([C:73]([F:76])([F:75])[F:74])[CH:50]=2)=[O:47])=[CH:44][CH:43]=1)[CH2:38][CH2:39][CH3:40]>>[CH2:37]([O:41][C:42]1[CH:78]=[CH:77][C:45]([C:46]([NH:48][C:49]2[CH:54]=[CH:53][C:52]([C:55]3[CH:63]=[C:62]4[C:58]([CH2:59][N:60]([C@@H:65]([CH:70]([CH3:71])[CH3:72])[C:66]([OH:68])=[O:67])[C:61]4=[O:64])=[CH:57][CH:56]=3)=[C:51]([C:73]([F:75])([F:76])[F:74])[CH:50]=2)=[O:47])=[CH:44][CH:43]=1)[CH2:38][CH2:39][CH3:40]