(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → HCID 53302656, compound

HRID 404018Notes

Reaction equation

HRID 404018 reaction equation
C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[CH3:37][O:38][C:39]1[CH:44]=[C:43]([NH:45][C:46](=[O:58])[C:47]2[CH:52]=[CH:51][C:50]([O:53][C:54]([F:57])([F:56])[F:55])=[CH:49][CH:48]=2)[CH:42]=[CH:41][C:40]=1[C:59]1[CH:67]=[C:66]2[C:62]([CH2:63][N:64]([C@@H:69]([CH:74]([CH3:76])[CH3:75])[C:70]([O:72]C)=[O:71])[C:65]2=[O:68])=[CH:61][CH:60]=1>>[CH3:37][O:38][C:39]1[CH:44]=[C:43]([NH:45][C:46](=[O:58])[C:47]2[CH:52]=[CH:51][C:50]([O:53][C:54]([F:55])([F:57])[F:56])=[CH:49][CH:48]=2)[CH:42]=[CH:41][C:40]=1[C:59]1[CH:67]=[C:66]2[C:62]([CH2:63][N:64]([C@@H:69]([CH:74]([CH3:76])[CH3:75])[C:70]([OH:72])=[O:71])[C:65]2=[O:68])=[CH:61][CH:60]=1

Participants

3

Reactant 2

HCID 67306402(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 131731569HCID 131731569, compound

Product 1

HCID 53302656HCID 53302656, compoundYield 82.2%

Procedure

The compound of example 464 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 463.

Sources & evidence

ORD record
ord-d44d1ea05c2548f28831488c44a2347e
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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