HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-methyl-4-nitrobenzene → HCID 131731570, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-methyl-4-nitrobenzene | HCID 251672 | — |
| Reactant | (S)-Methyl 3-methyl-2-(1-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-2-yl)butanoate | HCID 123866646 | — |
| Reactant | (S)-Methyl 3-methyl-2-(6-(5-nitropyridin-2-yl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731547 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131731570 | HCID 131731570 | 75% |
Reaction Steps
The compound of example 465 was prepared analogous to the compound of example 391 by reaction of the compound of example 390, 1-bromo-2-methyl-4-nitro benzene and Pd(dppf)Cl2: CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-da80050a7fb8441c9110bbf2d6d00137 |
| Source note | uspto-grants-2014_06 |