(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → HCID 67307584, compound

HRID 404023Notes

Reaction equation

HRID 404023 reaction equation
C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[CH3:37][CH:38]([CH3:75])[C@H:39]([N:44]1[CH2:52][C:51]2[C:46](=[CH:47][C:48]([C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60](=[O:72])[C:61]4[CH:66]=[CH:65][C:64]([CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])=[CH:63][CH:62]=4)=[CH:55][C:54]=3[CH3:73])=[CH:49][CH:50]=2)[C:45]1=[O:74])[C:40]([O:42]C)=[O:41]>>[CH3:75][CH:38]([CH3:37])[C@H:39]([N:44]1[CH2:52][C:51]2[C:46](=[CH:47][C:48]([C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60](=[O:72])[C:61]4[CH:62]=[CH:63][C:64]([CH2:67][CH2:68][CH2:69][CH2:70][CH3:71])=[CH:65][CH:66]=4)=[CH:55][C:54]=3[CH3:73])=[CH:49][CH:50]=2)[C:45]1=[O:74])[C:40]([OH:42])=[O:41]

Participants

3

Reactant 2

HCID 67306402(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 131731572HCID 131731572, compound

Product 1

HCID 67307584HCID 67307584, compoundYield 89%

Procedure

The compound of example 474 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 473.

Sources & evidence

ORD record
ord-5dc0eeaef58144bc999867ce274d0f96
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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