(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → HCID 67306431, compound

HRID 404028Notes

Reaction equation

HRID 404028 reaction equation
C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[Cl:37][C:38]1[CH:43]=[C:42]([NH:44][C:45](=[O:57])[C:46]2[CH:51]=[CH:50][C:49]([O:52][C:53]([F:56])([F:55])[F:54])=[CH:48][CH:47]=2)[CH:41]=[CH:40][C:39]=1[C:58]1[CH:66]=[C:65]2[C:61]([CH2:62][N:63]([C@@H:68]([CH:73]([CH3:75])[CH3:74])[C:69]([O:71]C)=[O:70])[C:64]2=[O:67])=[CH:60][CH:59]=1>>[Cl:37][C:38]1[CH:43]=[C:42]([NH:44][C:45](=[O:57])[C:46]2[CH:47]=[CH:48][C:49]([O:52][C:53]([F:54])([F:55])[F:56])=[CH:50][CH:51]=2)[CH:41]=[CH:40][C:39]=1[C:58]1[CH:66]=[C:65]2[C:61]([CH2:62][N:63]([C@@H:68]([CH:73]([CH3:75])[CH3:74])[C:69]([OH:71])=[O:70])[C:64]2=[O:67])=[CH:60][CH:59]=1

Participants

3

Reactant 2

HCID 67306402(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 131731575HCID 131731575, compound

Product 1

HCID 67306431HCID 67306431, compoundYield 72%

Procedure

The compound of example 488 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 487.

Sources & evidence

ORD record
ord-29ff0078a2b2475c847a2a38fd54b114
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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