HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-nitropyridine → HCID 131731576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-nitropyridine | HCID 817620 | — |
| Reactant | (S)-Methyl 3-methyl-2-(1-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-2-yl)butanoate | HCID 123866646 | — |
| Reactant | (S)-Methyl 3-methyl-2-(6-(5-nitropyridin-2-yl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731547 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131731576 | HCID 131731576 | 33% |
Reaction Steps
The compound of example 489 was prepared analogous to the compound of example 391 by reaction of the compound of example 390, 3-bromo-6-nitro pyridine and Pd(dppf)Cl2: CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-898ff3be29174d2c8b92568f086f8701 |
| Source note | uspto-grants-2014_06 |