HCID 53302768, compound → HCID 67307572, compound

HRID 404034Notes

Reaction equation

HRID 404034 reaction equation
C(C1C=CC(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(O)=O)C4=O)=CC=3)=NC=2)=O)=CC=1)(C)(C)C.[CH2:37]([O:41][C:42]1[CH:74]=[CH:73][C:45]([C:46]([NH:48][C:49]2[N:50]=[CH:51][C:52]([C:55]3[CH:63]=[C:62]4[C:58]([CH2:59][N:60]([C@@H:65]([CH:70]([CH3:72])[CH3:71])[C:66]([O:68]C)=[O:67])[C:61]4=[O:64])=[CH:57][CH:56]=3)=[N:53][CH:54]=2)=[O:47])=[CH:44][CH:43]=1)[CH2:38][CH2:39][CH3:40]>>[CH2:37]([O:41][C:42]1[CH:74]=[CH:73][C:45]([C:46]([NH:48][C:49]2[N:50]=[CH:51][C:52]([C:55]3[CH:63]=[C:62]4[C:58]([CH2:59][N:60]([C@@H:65]([CH:70]([CH3:71])[CH3:72])[C:66]([OH:68])=[O:67])[C:61]4=[O:64])=[CH:57][CH:56]=3)=[N:53][CH:54]=2)=[O:47])=[CH:44][CH:43]=1)[CH2:38][CH2:39][CH3:40]

Participants

3

Reactant 2

HCID 53302768HCID 53302768, compoundHCID 67306402(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

Product 1

HCID 67307572HCID 67307572, compoundYield 77%

Procedure

The compound of example 509 was prepared analogous to the compound of example 404 by hydrolysis of the compound of example 508.

Sources & evidence

ORD record
ord-c63a203c5da74fb08a1e37ff933ad93e
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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