Methyl 2-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)propanoate → HCID 67314997, compound

HRID 404043Notes

Reaction equation

HRID 404043 reaction equation
[CH3:1][C:2]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:26])([CH3:7])[C:3]([O:5][CH3:6])=[O:4].Br[C:28]1C=C2C(CN(C3(C(OC)=O)CCCC3)C2=O)=C[CH:29]=1>>[N+:23]([C:20]1[CH:21]=[CH:22][C:17]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][N:8]([C:2]4([C:3]([O:5][CH3:6])=[O:4])[CH2:1][CH2:29][CH2:28][CH2:7]4)[C:9]3=[O:26])=[CH:14][CH:13]=2)=[CH:18][CH:19]=1)([O-:25])=[O:24]

Participants

3

Reactant 2

HCID 67306803Methyl 2-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)propanoateHCID 67313241Methyl 1-(6-bromo-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

Product 1

HCID 67314997HCID 67314997, compoundYield 76%

Procedure

The compound of example 526 was prepared analogous to compound of example 514 by reaction of the compound of example 341 and

Sources & evidence

ORD record
ord-bc1e9bf79b1e45ee9f3fbec5a02b4260
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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