HCID 67314997, compound → Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

HRID 404044Notes

Reaction equation

HRID 404044 reaction equation
NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[N+:26]([C:29]1[CH:34]=[CH:33][C:32]([C:35]2[CH:43]=[C:42]3[C:38]([CH2:39][N:40]([C:45]4([C:50]([O:52][CH3:53])=[O:51])[CH2:49][CH2:48][CH2:47][CH2:46]4)[C:41]3=[O:44])=[CH:37][CH:36]=2)=[CH:31][CH:30]=1)([O-])=O>>[NH2:26][C:29]1[CH:30]=[CH:31][C:32]([C:35]2[CH:43]=[C:42]3[C:38]([CH2:39][N:40]([C:45]4([C:50]([O:52][CH3:53])=[O:51])[CH2:49][CH2:48][CH2:47][CH2:46]4)[C:41]3=[O:44])=[CH:37][CH:36]=2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 67314997HCID 67314997, compoundHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67314048Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopentanecarboxylateYield 77%

Procedure

The compound of example 527 was prepared analogous to the compound of example 6 by reduction of the compound of example 526.

Sources & evidence

ORD record
ord-4b8509ff591c40848c85c9de2941357d
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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