HRID404045

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74372

Benzoyl chloride, 4-(1,1-dimethylethyl)-

C11H13ClO

结构：COC(=O)C1(N2Cc3ccc(-c4ccc(N)cc4)cc3C2=O)CCCC1

HCID67314048

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(N2Cc3ccc(-c4ccc(NC(=O)c5ccc(C(C)(C)C)cc5)cc4)cc3C2=O)CCCC1

HCID70975438

未命名化合物

收率 79%

PROCEDURE

实验过程

The compound of example 530 was prepared analogous to compound of example 97 by reaction of compound of example 527 with 4-(t-butyl)benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efbe6fa4f296479a9bbe0837d1c414e0
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C:51]4([C:56]([O:58][CH3:59])=[O:57])[CH2:55][CH2:54][CH2:53][CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[C:60]([C:64]1[CH:72]=[CH:71][C:67]([C:68](Cl)=[O:69])=[CH:66][CH:65]=1)([CH3:63])([CH3:62])[CH3:61]>>[C:60]([C:64]1[CH:65]=[CH:66][C:67]([C:68]([NH:34][C:35]2[CH:36]=[CH:37][C:38]([C:41]3[CH:49]=[C:48]4[C:44]([CH2:45][N:46]([C:51]5([C:56]([O:58][CH3:59])=[O:57])[CH2:55][CH2:54][CH2:53][CH2:52]5)[C:47]4=[O:50])=[CH:43][CH:42]=3)=[CH:39][CH:40]=2)=[O:69])=[CH:71][CH:72]=1)([CH3:63])([CH3:61])[CH3:62]