(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → 1-(6-(4-(4-(tert-Butyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)cyclopentane carboxylic acid

HRID 404046Notes

Reaction equation

HRID 404046 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[C:33]([C:37]1[CH:70]=[CH:69][C:40]([C:41]([NH:43][C:44]2[CH:49]=[CH:48][C:47]([C:50]3[CH:58]=[C:57]4[C:53]([CH2:54][N:55]([C:60]5([C:65]([O:67]C)=[O:66])[CH2:64][CH2:63][CH2:62][CH2:61]5)[C:56]4=[O:59])=[CH:52][CH:51]=3)=[CH:46][CH:45]=2)=[O:42])=[CH:39][CH:38]=1)([CH3:36])([CH3:35])[CH3:34]>>[C:33]([C:37]1[CH:70]=[CH:69][C:40]([C:41]([NH:43][C:44]2[CH:45]=[CH:46][C:47]([C:50]3[CH:58]=[C:57]4[C:53]([CH2:54][N:55]([C:60]5([C:65]([OH:67])=[O:66])[CH2:61][CH2:62][CH2:63][CH2:64]5)[C:56]4=[O:59])=[CH:52][CH:51]=3)=[CH:48][CH:49]=2)=[O:42])=[CH:39][CH:38]=1)([CH3:36])([CH3:34])[CH3:35]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 70975438Methyl 1-(6-(4-(4-(tert-butyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)cyclopentanecarboxylate

Product 1

HCID 533027691-(6-(4-(4-(tert-Butyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)cyclopentane carboxylic acidYield 62%

Procedure

The compound of example 531 was prepared analogous to compound of example 98 by hydrolysis of compound of example 530.

Sources & evidence

ORD record
ord-81a8587104d049a7b64d28db23296b65
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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