(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67305945, compound

HRID 404052Notes

Reaction equation

HRID 404052 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[O:33]=[C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[C:40]([C:43]3[CH:48]=[CH:47][C:46]([NH:49][C:50](=[O:62])[C:51]4[CH:56]=[CH:55][C:54]([CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])=[CH:53][CH:52]=4)=[CH:45][CH:44]=3)[CH:41]=2)[CH2:36][N:35]1[C:63]1([C:68]([O:70]C)=[O:69])[CH2:67][CH2:66][CH2:65][CH2:64]1>>[O:33]=[C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[C:40]([C:43]3[CH:44]=[CH:45][C:46]([NH:49][C:50](=[O:62])[C:51]4[CH:56]=[CH:55][C:54]([CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])=[CH:53][CH:52]=4)=[CH:47][CH:48]=3)[CH:41]=2)[CH2:36][N:35]1[C:63]1([C:68]([OH:70])=[O:69])[CH2:64][CH2:65][CH2:66][CH2:67]1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 67306702Methyl 1-(1-oxo-6-(4-(4-pentylbenzamido)phenyl)isoindolin-2-yl)cyclopentane carboxylate

Product 1

HCID 67305945HCID 67305945, compoundYield 84%

Procedure

The compound of example 537 was prepared analogous to compound of example 98 by hydrolysis of compound of example 536.

Sources & evidence

ORD record
ord-ea16c225caa64740adb995e3e0b16389
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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