HRID404063

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID318530

5-methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride

C11H8ClNO2

结构：COC(=O)C1CCCC(N2Cc3ccc(-c4ccc(N)cc4)cc3C2=O)C1

HCID67315555

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1CCCC(N2Cc3ccc(-c4ccc(NC(=O)c5nc(-c6ccccc6)oc5C)cc4)cc3C2=O)C1

HCID67307309

未命名化合物

收率 65%

PROCEDURE

实验过程

The compound of example 552 was prepared analogous to compound of example 97 by reaction of compound of example 543 with 5-methyl-2-phenyloxazole-4-carbonyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bebecdf65bb6493ab15916fda32ff09b
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC([C:16]2[CH:24]=[C:23]3[C:19](C[N:21]([C@@H:26]([CH:31]([CH3:33])C)[C:27](OC)=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([CH:51]4[CH2:56][CH2:55][CH2:54][CH:53]([C:57]([O:59][CH3:60])=[O:58])[CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.CC1OC(C2C=CC=CC=2)=NC=1C(Cl)=O>>[CH3:33][C:31]1[O:25][C:22]([C:23]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:24]=2)=[N:21][C:26]=1[C:27]([NH:34][C:35]1[CH:36]=[CH:37][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([CH:51]4[CH2:56][CH2:55][CH2:54][CH:53]([C:57]([O:59][CH3:60])=[O:58])[CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:39][CH:40]=1)=[O:28]