5-Methyl-2-phenyl-1,3-oxazole-4-carbonyl chloride → HCID 67307309, compound

HRID 404063Notes

Reaction equation

HRID 404063 reaction equation
C(NC1C=CC([C:16]2[CH:24]=[C:23]3[C:19](C[N:21]([C@@H:26]([CH:31]([CH3:33])C)[C:27](OC)=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([CH:51]4[CH2:56][CH2:55][CH2:54][CH:53]([C:57]([O:59][CH3:60])=[O:58])[CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.CC1OC(C2C=CC=CC=2)=NC=1C(Cl)=O>>[CH3:33][C:31]1[O:25][C:22]([C:23]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:24]=2)=[N:21][C:26]=1[C:27]([NH:34][C:35]1[CH:36]=[CH:37][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([CH:51]4[CH2:56][CH2:55][CH2:54][CH:53]([C:57]([O:59][CH3:60])=[O:58])[CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:39][CH:40]=1)=[O:28]

Participants

4

Reactant 3

HCID 3185305-Methyl-2-phenyl-1,3-oxazole-4-carbonyl chlorideHCID 67315555Methyl 3-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclohexanecarboxylateHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307309HCID 67307309, compoundYield 65%

Procedure

The compound of example 552 was prepared analogous to compound of example 97 by reaction of compound of example 543 with 5-methyl-2-phenyloxazole-4-carbonyl chloride.

Sources & evidence

ORD record
ord-bebecdf65bb6493ab15916fda32ff09b
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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