(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67307636, compound

HRID 404064Notes

Reaction equation

HRID 404064 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][C:34]1[O:38][C:37]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[N:36][C:35]=1[C:45]([NH:47][C:48]1[CH:53]=[CH:52][C:51]([C:54]2[CH:62]=[C:61]3[C:57]([CH2:58][N:59]([CH:64]4[CH2:69][CH2:68][CH2:67][CH:66]([C:70]([O:72]C)=[O:71])[CH2:65]4)[C:60]3=[O:63])=[CH:56][CH:55]=2)=[CH:50][CH:49]=1)=[O:46]>>[CH3:33][C:34]1[O:38][C:37]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[N:36][C:35]=1[C:45]([NH:47][C:48]1[CH:49]=[CH:50][C:51]([C:54]2[CH:62]=[C:61]3[C:57]([CH2:58][N:59]([CH:64]4[CH2:69][CH2:68][CH2:67][CH:66]([C:70]([OH:72])=[O:71])[CH2:65]4)[C:60]3=[O:63])=[CH:56][CH:55]=2)=[CH:52][CH:53]=1)=[O:46]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 67307309HCID 67307309, compound

Product 1

HCID 67307636HCID 67307636, compoundYield 72%

Procedure

The compound of example 553 was prepared analogous to compound of example 98 by hydrolysis of compound of example 552.

Sources & evidence

ORD record
ord-d935039bbece4bb989de40a7ed265412
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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